Region: Shawnee Hills
Manager: Shawnee National Forest (link)
The smallest Wilderness in the AIM area, the United States Congress designated Panther Den as a wilderness area in 1990. It now has a total of 1195 acres, 1081 acres is National Forest System and other portion is the Crab Orchard Wilderness. The primary trail system is the River to River Trail. This trail is well marked and has several loops are in the system. Several other trails branch off the River to River Trail and support the main trail system.